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Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer (METERMUCADIG)

Purpose Undernutrition associated with cancer, or cancer cachexia results from a deterioration of the energy balance that leads to a gradual mobilization of energy reserves in the body and to increasing deterioration of the nutritional status of patients. This will thus significantly reduce quality of life and survival of patients with a lower tolerance to cancer treatments. Despite undeniable progress in knowledge, many pathophysiological mechanisms remain few or not explored, which could explain that there is still no satisfactory therapeutic solution to halt the gradual deterioration of the nutritional status of patients. In this sense, apart from preclinical data obtained in animal models, there is currently no clinical study on the functioning of skeletal muscle energy metabolism in undernourished patients suffering of cancer.
Recruitment This study is not yet open for participant recruitment.
Condition Undernutrition; Gastrointestinal Cancer
Intervention Other: Samples
Outcome Measures
Primary Outcome Measures:
  • Measurement of muscle mitochondrial bioenergetics [ Time Frame: An average of one week ] [ Designated as safety issue: No ]
    Measurement of muscle mitochondrial bioenergetics by high resolution oxygraphy
Secondary Outcome Measures:
  • Quantification of muscle lipid droplets [ Time Frame: An average of one week ] [Designated as safety issue: No ]
    Quantification of muscle lipid droplets by electron microscopy.
  • Analysis of the expression of target genes and proteins [ Time Frame: An average of one week ] [ Designated as safety issue: No ]
    Analysis of the expression of target genes and proteins involved in 1/ mitochondrial metabolism 2/ lipid metabolism 3/ the regulation of energy metabolism and 4/ muscle proteolysis by RTqPCR with SYBR Green and by Western Blot.
  • Determination of body composition (fat mass / lean mass) [ Time Frame: Within 4 weeks before inclusion ] [ Designated as safety issue: No ]
    Determination of body composition ( fat mass / lean mass ) by an imaging method scannographic.
  • Determining the isotopic composition of nitrogen hair [ Time Frame: An average of one week ] [ Designated as safety issue: No ]
    Determining the isotopic composition of nitrogen hair spectrometry.
Locations and Contacts
Contact
Thierry LECOMTE, MD-PhD; +33(0)2.47.47.59.00; thierry.lecomte@univ-tours.fr
Stéphane SERVAIS, PhD; +33(0)2.47.36.60.59; stephane.servais@univ-tours.fr

Location
France
Service d'Hépato-gastroentérologie et de Cancérologie Digestive, CHRU de TOURS - Not yet recruiting
Tours, France, 37044
Contact: Thierry LECOMTE MD-PhD, +3(0)2.47.47.59.00; thierry.lecomte@univ-tours.fr
More Info clinicaltrials.gov/ct2/show/NCT02573974

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