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Mitochondrial Respiratory Function in Mammalian Skeletal Muscle

Purpose The purpose of this study is to determine whether skeletal muscle mitochondrial function is altered in patients with head and neck cancer compared to healthy controls.
Recruitment This study is currently recruiting participants.
Condition Cachexia; Cancer
Intervention Not Provided
Outcome Measures
Primary Outcome Measures:
  • Baseline skeletal muscle oxygen consumption (pmol O2/s*mg) in head and neck cancer patients and healthy age-matched controls [Time Frame: Baseline] [Designated as safety issue: No].
    Aerobic respiration will be measured from skeletal muscle biopsies of the vastus lateralis using Oroboros O2K high resolution respirometry. The average maximal skeletal muscle oxygen consumption of 10 head and neck cancer subjects will be compared to the average of 10 healthy controls.
Secondary Outcome Measures:
  • Skeletal muscle oxygen consumption (pmol O2/s*mg) in head and neck cancer patients following 4 weeks of standard of care. [Time Frame: 4 weeks] [Designated as safety issue: No]
    Aerobic respiration will be measured from skeletal muscle biopsies of the vastus lateralis using Oroboros O2K high resolution respirometry. The average maximal skeletal muscle oxygen consumption of 10 head and neck cancer subjects after 4 weeks of standard of care (including chemotherapy, corticosteroids, etc. as prescribed by physician) will be compared to the average of their baseline measures.
Locations and Contacts
Contacts
Kate M Randolph, BS; +409-772-8126; kmrandol@utmb.edu
Tray Wright, PhD; +409-772-2525; tjwright@utmb.edu

Locations
United States, Texas
The University of Texas Medical Branch - Recruiting
Galveston, Texas, United States, 77555
Contact: Kate Randolph, BS; +09-772-8126; kmrandol@utmb.edu
Principal Investigator: Melinda Sheffield-Moore, PhD
More Info clinicaltrials.gov/ct2/show/NCT02650570

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