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STAT3 in the systemic inflammation of cancer cachexia

Zimmers TA, Fishel ML, Bonetto A.
Semin Cell Dev Biol. 2016 Feb 6. pii: S1084-9521(16)30051-9. doi: 10.1016/j.semcdb.2016.02.009. [Epub ahead of print]
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Presence of the tumor elicits an inflammatory response and profound metabolic derangements involving not only muscle and fat, but also the hypothalamus, liver, heart, blood, spleen and likely other organs. 

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